Structural, biological and pharmaceutical importance of antibiotic agent chloramphenicol
نویسندگان
چکیده
منابع مشابه
performance of biological system and advanced oxidation processes (aop) treating antibiotic production industrial wastewater
در این مطالعه، عملکرد دو سیستم اکسیداسیون شیمیایی پیشرفته و یک سیستم بیولوژیکی برای حذف آموکسی سیلین در فاضلاب های سنتزیدر غلظت های مشابه با موارد صنعتی مورد بررسی قرار گرفته شدند. مطالعه انجام شده دارای سه بخش متفاوت اکسیداسیون با ازن و اشعه uv، اکسیداسیون با استفاده از نانو فتوکاتالیست tio2 و استفاده از بیوراکتور هوازی لجن فعال با جداکننده های فیزیکی می باشد. در هر بخش، متغیر های متفاوتی متنا...
15 صفحه اولTracking of chloramphenicol, erythromycin, and sulfamethoxazole antibiotic-resistant bacteria from untreated wastewater effluents to receiving river
Background: The aim of this study was to investigate the frequency and type of bacteria resistant to chloramphenicol (CHL), erythromycin (E), and sulfamethoxazole (SXT) antibiotics from untreated wastewater effluents to receiving river. Methods: In total, 32 samples were taken from eight sites located in the raw wastewater to the downstream of the receiving Ghotor river in Khoy city. Resistant...
متن کاملThe antibiotic chloramphenicol may be an effective new agent for inhibiting the growth of multiple myeloma
Chloramphenicol is an old antibiotic that also inhibits mammalian mitochondrial protein synthesis. Our studies demonstrated that chloramphenicol is highly cytotoxic to myeloma cells, acting in a dose- and time-dependent manner. Chloramphenicol sharply suppressed ATP levels in myeloma cells at concentrations ≥ 25 μg/mL. Colorimetric and clonogenic assays indicate that chloramphenicol inhibits gr...
متن کاملSynthesis and antibiotic properties of chloramphenicol reduction products.
Analogs of chloramphenicol were prepared for the first time in which the nitro group was replaced by hydroxylamine, nitroso, hydroxamic acid, methyl hydroxamate, and O-acetyl hydroxamate functional groups. These compounds were tested for antibiotic activity in order to determine whether the antibiotic activity of chloramphenicol is mediated by one or more of these potential metabolites of chlor...
متن کاملTinkering with antibiotic resistance: chloramphenicol acetyltransferase and its substrates.
Chloraniphcnicol acctyltransfcrase ( C A T ) ( E C 7.3.1.78) catalyses the 0-acetylation and inactivation of the antibiotic, using acetyl-CoA a s the acyl donor. T h e structural gene for CAT in chlor~rmphenicol-resistant bacteria may be chromosomal. hut in most genera has been observed t o be plasmidborne. All known variants have similar subunit molecular masses ( 75 k l h ) and a high degree ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Heliyon
سال: 2020
ISSN: 2405-8440
DOI: 10.1016/j.heliyon.2020.e03433